Paradoxically Augmented Anti-Tumorigenic Action of Proton Pump Inhibitor and Gastrin in APCMin/+ Intestinal Polyposis Model1
نویسندگان
چکیده
منابع مشابه
Proton pump inhibitor-induced fundic gland polyposis
A 42-year-old woman presented with recurrent acid regurgitation and heartburn. On initial upper endoscopy, multiple mucosal breaks were seen in the lower esophagus, but no abnormalities were observed in the stomach (Fig. 1). The patient took proton pump inhibitors for consistent reflux symptoms and reflux esophagitis. On follow-up endoscopy 4 years later, confluence of mucosal breaks and stenos...
متن کاملChemopreventive Action of Anthocyanin-rich Black Soybean Fraction in APCMin/+ Intestinal Polyposis Model
BACKGROUND Anthocyanins have been shown to inhibit cancer cell growth by suppressing oxidative stress and inflammatory responses. The purpose of this study was to investigate the effects of an anthocyanin-rich extract (AE) from black soybean coat on intestinal carcinogenesis. METHODS Apc (Min/+) mice were fed a diet of 0.2% or 0.5% AE for 7 weeks. We analyzed the number of intestinal tumors, ...
متن کاملSuppression of intestinal polyposis in Mdr1-deficient ApcMin/+ mice.
Aberrant transactivation of a certain set of target genes by the beta-catenin and T-cell factor/lymphoid enhancer factor complex has been considered crucial for the initiation of intestinal tumorigenesis. The human multidrug resistance (MDR)1 (ABCB1) gene contains multiple beta-catenin-T-cell factor4-binding elements in its promoter and is one of the immediate targets of the complex. In the cur...
متن کاملNormal and proton pump inhibitor-mediated gastrin levels in infants 1 to 11 months old.
BACKGROUND Scant data exist on the normal range of serum gastrin in infants. In phase I and III trials of rabeprazole in gastroesophageal reflux disease, we studied serum gastrin levels in infants 1 to 11 months old, and assessed normal ranges and the effect of acid-suppressive drugs. METHODS Overall, 349 treatment-naïve or treatment-experienced (previously exposed to proton pump inhibitors a...
متن کاملMassive fundic gland polyposis in a patient receiving protracted proton-pump inhibitor medication.
A case of massive fundic gland polyposis (MFGPsis) in a female patient receiving protracted proton-pump inhibitor (PPI) medication is described. At gross examination the majority of the polyps were overlapping, confluent, some of them having a "cauliflower-like" configuration. The fundic gland polyps (FGP) arose in the gastric acid secretory mucosa. The confluence of these polyps impeded their ...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2014
ISSN: 1476-5586
DOI: 10.1593/neo.131510